André Øvredal has started casting The Autopsy of Jane Doe, and will shoot the film in London this winter.
The film follows a father-and-son team of coroners in a small-town mortuary carrying out an autopsy on a young murder victim, as they uncover increasingly bizarre clues on her cause of death.
"The Autopsy of Jane Doe has everything I want in a horror movie - great characters, an intriguing mystery and it is simply the scariest scripts I have ever read," Øvredal said.
"I am proud to make this my follow-up to Troll Hunter and I am excited to be in business with Goldcrest."
Goldcrest films, famous for producing 1980s classics such as Gandhi and Chariots of Fire, has relaunched in recent years, working on films such as the Margaret Thatcher biopic The Iron Lady.
Trollhunter, released in 2011, grossed some $4m on a $3.5 million budget, but has gained something of a cult following among aficionados of kooky fantasy and horror films.